First Report and 3D Reconstruction of a Presumptive Microscopic Liver Lipoma in a Black Barbel (Barbus balcanicus) from the River Bregalnica in the Republic of North Macedonia

A lipoma is a benign tumour of mature adipocytes which may appear in various species, including marine and freshwater fish. It usually occurs isolated locations, such as superficial or deep mass, mainly the skin seldom other organs. In non-mammalian vertebrates, there no agreed minimal size for mass to be considered lipoma. This study histologically describes case proposed microlipoma liver Barbus balcanicus. The structure was an oval-shaped well-differentiated adipocytes, surrounded by hepatic parenchyma. adipocyte cluster did not contact with major vascular biliary tracts, capsule, hilum. cell reached maximal linear length width ~0.5 mm ~0.4 mm. three-dimensional software-assisted reconstruction adipocytic showed that it had shape flattened prolate spheroid (~0.01 mm3). Given histological criteria currently used literature, we consider lipoma, or, better, because tiny. We interpret this early growing work second description fish best our knowledge.